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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: metastasis of tumors and the effect of medicine against cells, a new murine ascites hepatocarcinomaMurine ascites hepatocarcinoma cell strain with low lymphatic metastatic potential (Hca-P) was subcutaneouslyThe sensitivity of two murine ascites hepatocarcinoma cell lines (Hca-P and Hca-P/L ) and two anchorage-dependentCurcumin had significant growth inhibiting effect on both murine ascites and human hepatocarcinoma cellAt concentrations of 30-120 μmol/L, curcumin had more inhibition on murine ascites hepatocarcinoma cell

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelSyngeneic hematopoietic stem cell transplantation (HSCT) mice served as controls.immunohistochemistry the present study demonstrated that there was strong PAR-1, 2 immunoreactivity in the epithelial celland vascular endothelial cell of target organs of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: Hepatocellular carcinoma (HCC), which makes up the majority of liver cancer, is induced by the infection of hepatitis B/C virus. Biomarkers are needed to facilitate the early detection of HCC, which is often diagnosed too late for effective therapy. The tRNA-derived small RNAs (tsRNAs) play vital roles in tumorigenesis and are stable in circulation. However, the diagnostic values and biological functions of circulating tsRNAs, especially for HCC, are still unknown. In this study, we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serum. We identified tRF-Gln-TTG-006, which was remarkably upregulated in HCC serum (training cohort: 24 HCC patients vs. 24 healthy controls). In the validation stage, we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity (80.4%) and specificity (79.4%) even in the early stage (Stage I: sensitivity, 79.0%; specificity, 74.8%; 155 healthy controls vs. 153 HCC patients from two cohorts). Moreover, in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells, and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis assays. In summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA     biomarker     hepatocarcinoma    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cellline A549

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: cycle control of the lung cancer cell line A549.Cell proliferation was assessed by cell counting kit-8 (CCK-8).Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resultedin reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis andthe interruption of cell cycle transition.

Keywords： control     interruption     cytoplasm     number     growth    

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cellsCurrent NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potentiallines and genetically modifying fresh NK cells or NK cell lines.The stable allogeneic NK cell line approach is more practical for quality-control and large-scale productionIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 766-772 doi: 10.1007/s11684-021-0916-8

Abstract: Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapiesThis study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapyFor patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated

Keywords： anlotinib     chemotherapy     short-term relapsed     small-cell lung cancer    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cellline via ERKs pathway

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: investigate the extracellular regulated protein kinases (ERKs) pathway of HBx on glomerular mesangial cellPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.HBx upregulates TNF-α expression and induces cell proliferation of GMC line partly through ERK signal

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murine

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murine

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL system and Fas-mediated apoptosis in cellline HL-60 cells.

Keywords： nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cells and murine

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: Murine Rip2 small interfering RNA (siRNA) plasmids were constructed and transfected into macrophage andCell proliferation was assayed with MTT. TNF-?Rip2 siRNA plasmid could block the mRNA and protein expression of Rip2 and promote cell proliferation
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Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: The dendritic cell vaccine is a treatment vaccine with potent clinical applications.Functional cytokines can enhance dendritic cell anti-tumor immune responses.

Keywords： Functional     experiment     anti-tumor     dendritic     clinical    

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transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant hepatocarcinoma

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 120-128 doi: 10.1007/s11684-017-0501-3

Abstract: To prolong the retention of 131I-MIBG in target cells, we infected hepatocarcinoma (HepG2obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell

Keywords： norepinephrine transporter     vesicular monoamine transporter 2     -MIBG     gene therapy     lentivirus vector    

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Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

Hongbo TANG MD, Zirong YE MM, Yuping REN MD, Zhanyong ZHU MD, Yiping WU MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 421-425 doi: 10.1007/s11684-009-0078-6

Abstract: A murine primary mammary tumor model was established to investigate the treatment with ginsenosides Rg3The cell cycle and apoptosis percentage were determined by means of flow cytometry.Ginsenoside Rg3 can play an antitumor role in primary mammary tumor model by inhibiting angiogenesis, cellcycle progression, and promoting cell apoptosis.

Keywords： ginsenoside Rg3     mammary tumor     mice    

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Acoustic fault signal extraction via the line-defect phononic crystals

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 1,   Pages 10-10 doi: 10.1007/s11465-021-0666-y

Abstract: In this paper, 2D line-defect phononic crystals (PCs) consisting of periodic acrylic tubes with slitThe defect band, namely, the formed resonance band of line-defect PCs enables the incident acoustic waveThe effectiveness of weak harmonic and periodic impulse signal detection via line-defect PCs are investigatedAll the numerical and experimental results indicate that line-defect PCs can be well used for extracting

Keywords： phononic crystals     line-defect     fault signal extraction     acoustic enhancement    

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Title Author Date Type Operation

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cellline A549

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cellline via ERKs pathway

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murine

Journal Article

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant hepatocarcinoma

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Journal Article

Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

Hongbo TANG MD, Zirong YE MM, Yuping REN MD, Zhanyong ZHU MD, Yiping WU MD,

Journal Article

Acoustic fault signal extraction via the line-defect phononic crystals

Journal Article